Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.nlm.2016.07.017
Title: The forebrain medial septal region and nociception
Authors: ANG SEOK TING 
MOHAMMED ZACKY ARIFFIN 
Khanna,Sanjay 
Keywords: Affect
Aversion
Forebrain regulation
Formalin model
Persistent/long-lasting pain
Sensorimotor
Issue Date: 1-Feb-2017
Publisher: Elsevier
Citation: ANG SEOK TING, MOHAMMED ZACKY ARIFFIN, Khanna,Sanjay (2017-02-01). The forebrain medial septal region and nociception. Neurobiology of Learning and Memory 138 : 238-251. ScholarBank@NUS Repository. https://doi.org/10.1016/j.nlm.2016.07.017
Abstract: The forebrain medial septum, which is an integral part of the septo-hippocampal network, is implicated in sensorimotor integration, fear and anxiety, and spatial learning and memory. A body of evidence also suggests that the septal region affects experimental pain. Indeed, some explorations in humans have raised the possibility that the region may modulate clinical pain as well. This review explores the evidence that implicates the medial septum in nociception and suggests that non-overlapping circuits in the region facilitate acute nociceptive behaviors and defensive behaviors that reflect affect and cognitive appraisal, especially in relation to persistent nociception. In line with a role in nociception, the region modulates nociceptive responses in the neuraxis, including the hippocampus and the anterior cingulate cortex. The aforementioned forebrain regions have also been implicated in persistent/long-lasting nociception. The review also weighs the effects of the medial septum on nociception vis-à-vis the known roles of the region and emphasizes the fact that the region is a part of network of forebrain structures which have been long associated with reward, cognition and affect-motivation and are now implicated in persistent/long-lasting nociception.
Source Title: Neurobiology of Learning and Memory
URI: http://scholarbank.nus.edu.sg/handle/10635/137801
ISSN: 10747427
DOI: 10.1016/j.nlm.2016.07.017
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

2
checked on Nov 13, 2018

WEB OF SCIENCETM
Citations

2
checked on Nov 13, 2018

Page view(s)

185
checked on Nov 15, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.