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Title: Optimal operation of simulated moving bed and varicol processes for bio-separation
Keywords: Simulated Moving Bed; Varicol; SB-553261; 1,1’-bi-2-naphtol; Genetic Algorithm; Optimization
Issue Date: 16-Jan-2004
Source: FALDY WONGSO (2004-01-16). Optimal operation of simulated moving bed and varicol processes for bio-separation. ScholarBank@NUS Repository.
Abstract: Simulated moving bed (SMB) technology and its modification, Varicol process, has become an alternate technology for separation of difficult or nearly impossible mixtures. In this technology, separation of two components is achieved by simulating countercurrent movement of solid and liquid phases. In traditional SMB process, a synchronous switch of all the inlet and outlet and streams are performed while in the Varicol process a non-synchronous switch is employed to render more flexibility to the system. Equilibrium dispersive model coupled with lumped kinetic approximation and non-linear equilibrium isotherm constitute the simulation model, which was verified with published experimental results for two systems: enantioseparation of SB-553261 (chiral drugs) and 1,1a??-bi-2-naphtol (chiral intermediates). Single and multiple objective optimization studies were carried out for many different meaningful optimization formulations. Use of non-dominated sorting genetic algorithm with jumping genes resulted in Pareto optimal solutions, which can easily be explained by Triangle theory. Optimal operating conditions and optimal Pareto solutions clearly show that the concept of multi-objective optimization could be very useful in the design and operation of SMB and Varicol process for many important industrial applications.
Appears in Collections:Master's Theses (Open)

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