Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/137341
Title: INVESTIGATION OF CORTICAL WAVES IN MAMMALIAN CELL DIVISION
Authors: XIAO SHENG PING
Keywords: pattern, wave, mitosis, size, Cdc42, FBP17
Issue Date: 16-Jan-2017
Source: XIAO SHENG PING (2017-01-16). INVESTIGATION OF CORTICAL WAVES IN MAMMALIAN CELL DIVISION. ScholarBank@NUS Repository.
Abstract: Dynamic spatial patterns such as travelling waves could theoretically encode spatial information, but little is known about whether or how they are employed by biological systems, especially higher eukaryotes. Here I show that mitotic cortical waves of active Cdc42 and the F-BAR protein FBP17 appear on the cell cortex at the onset of mitosis. Interestingly, the mitotic waves correlate with chromosome misalignment during metaphase which also link to the spindle assembly checkpoint. Intriguingly, mitotic cortical waves appear in cells experiencing anaphase spindle rotations, suggesting that these waves encode additional spatial information for furrow positioning that is not specified by the metaphase spindle. Moreover, unlike interphase cortical waves, the frequencies and wavelengths of the mitotic waves are proportional to mitotic cell sizes. These data suggest that mitotic cortical waves of Cdc42 and F-BAR proteins integrate positional and cell size information in modulating the final sites of division.
URI: http://scholarbank.nus.edu.sg/handle/10635/137341
Appears in Collections:Ph.D Theses (Open)

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