Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/13723
Title: Sulphite oxidase in sulphite metabolism and toxicity
Authors: WOO WEE HONG
Keywords: Sulphite oxidase, sulphite, differential expression, gene induction, rats and humans
Issue Date: 20-Feb-2004
Source: WOO WEE HONG (2004-02-20). Sulphite oxidase in sulphite metabolism and toxicity. ScholarBank@NUS Repository.
Abstract: Sulphite oxidase is a molybdopterin-containing enzyme that is ubiquitous in animals and physiologically catalyzes the oxidation of sulphite to sulphate. The expression of the sulphite oxidase gene in human and rat tissues was investigated and was found that the human liver, kidney, skeletal muscle, heart, placenta and brain showed substantial expression while thymus, spleen, peripheral blood leucocytes, colon, small intestine and lung showed little expression in humans. In rat, the liver, kidney, heart, brain and lung (but not skeletal muscle) revealed a hybridization signal with the strongest signal in the liver. The spleen and testis also showed little expression. Expression of sulphite oxidase gene was seen in all human brain regions examined (cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, amygdala, caudate nucleus, corpus callosum, hippocampus, thalamus, temporal lobe and putamen). The cerebral cortex showed the highest level of expression. Attempts to elucidate the regulation of gene expression were unsuccessful.
URI: http://scholarbank.nus.edu.sg/handle/10635/13723
Appears in Collections:Master's Theses (Open)

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