Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/137206
Title: EPIGENETIC REGULATION OF SYNAPTIC PLASTICITY AND ASSOCIATIVITY IN HIPPOCAMPAL AREA CA1 BY G9a/GLP COMPLEX
Authors: MAHIMA SHARMA
ORCID iD:   orcid.org/0000-0003-0860-7854
Keywords: Epigenetics in Memory, G9a-GLP complex, Histone methylation, Long-term Potentiation, Synaptic tagging/Capture, Alzheimer's Disease
Issue Date: 16-May-2017
Source: MAHIMA SHARMA (2017-05-16). EPIGENETIC REGULATION OF SYNAPTIC PLASTICITY AND ASSOCIATIVITY IN HIPPOCAMPAL AREA CA1 BY G9a/GLP COMPLEX. ScholarBank@NUS Repository.
Abstract: Epigenetic regulations play an important role in learning and memory processes. G9a/GLP methyltransferase complex controls a prominent histone3 lysine9 dimethylation (H3K9me2). In this study, using cellular models of memory such as long-term potentiation (LTP) and synaptic tagging/capture (STC) in acute hippocampal slices of rats, we have investigated how the catalytic inhibition of G9a/GLP complex affects the encoding and maintenance of memories. The catalytic inhibition of G9a/GLP complex leads to the reinforcement of early-LTP that also participates in synaptic tagging/capture. Brain derived neurotrophic factor (BDNF) mediated these effects. This study also provides evidence for the G9a/GLP complex inhibition mediated restoration of altered plasticity and associativity in Aβ (1-42) oligomer-treated rat hippocampal neurons and CA1 pyramidal neutrons of APP/PS1 mice, and identifies the crucial role of BDNF signaling in alleviating synaptic plasticity impairments in the rat hippocampal neurons resulting from Aβ (1-42) exposure.
URI: http://scholarbank.nus.edu.sg/handle/10635/137206
Appears in Collections:Ph.D Theses (Restricted)

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