Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/137144
Title: | VITAMIN E ISOFORM ¿-TOCOTRIENOL ALLEVIATES ASTHMA AND COPD | Authors: | PEH HONG YONG | Keywords: | Inflammation, Oxidative Damage, Airway Hyperresponsiveness, Emphysema, Antioxidant, Corticosteroid | Issue Date: | 16-Oct-2017 | Citation: | PEH HONG YONG (2017-10-16). VITAMIN E ISOFORM ¿-TOCOTRIENOL ALLEVIATES ASTHMA AND COPD. ScholarBank@NUS Repository. | Abstract: | Inflammation and oxidative stress contribute to the pathogenesis of both asthma and chronic obstructive pulmonary disease (COPD). Although corticosteroid is the first-line treatment for asthma and COPD, a subset of patients is steroid-resistant, and chronic steroid use causes side effects. As vitamin E isoform γ-tocotrienol possesses both anti-oxidative and anti-inflammatory properties, we aimed to determine effects of γ-tocotrienol in a house dust mite (HDM) experimental asthma model and cigarette smoke experimental COPD model. We have shown for the first time the efficacy of vitamin E isoform γ-tocotrienol in protection against HDM-induced asthma and cigarette smoke-induced COPD by direct neutralization of free radicals, abating oxidative damage, and restoring antioxidants activities, coupled with anti-inflammatory actions in the injured airways. Mechanistically, γ-tocotrienol was found to block nuclear STAT3 and NF-κB level, and enhance nuclear Nrf2 levels in lung lysates to greater extents than prednisolone. | URI: | http://scholarbank.nus.edu.sg/handle/10635/137144 |
Appears in Collections: | Ph.D Theses (Open) |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
PehHY.pdf | 6.47 MB | Adobe PDF | OPEN | None | View/Download |
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.