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https://scholarbank.nus.edu.sg/handle/10635/13672
DC Field | Value | |
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dc.title | Analysis of the multisubunit exocyst complex in schizosaccharomyces pombe | |
dc.contributor.author | WANG HONGYAN | |
dc.date.accessioned | 2010-04-08T10:35:22Z | |
dc.date.available | 2010-04-08T10:35:22Z | |
dc.date.issued | 2004-02-16 | |
dc.identifier.citation | WANG HONGYAN (2004-02-16). Analysis of the multisubunit exocyst complex in schizosaccharomyces pombe. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/13672 | |
dc.description.abstract | Cytokinesis in fission yeast Schizosaccharomyces pombe is achieved by the use of an actomyosin ring and the centripetal deposition of a division septum. Cleavage of the inner layer of the division septum results in the liberation of daughter cells. In this study, the essential role of a multi-protein complex exocyst in cell separation is described. Exocyst proteins localize to regions of active exocytosis and form a complex in vivo in S. pombe. Exocyst mutants appear to be able to elongate and assemble division septa, but are defective for cell separation. I therefore propose that the fission yeast exocyst may be involved in targeting of enzymes responsible for septum cleavage. The interaction of the exocyst with Rho3p, a member of the Rho family of small GTPase, suggesting that S. pombe Rho3p may regulate cell separation by modulating exocyst function. | |
dc.language.iso | en | |
dc.subject | S. pombe, cytokinesis, exocytosis, exocyst complex, Rho3p | |
dc.type | Thesis | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.contributor.supervisor | MOHAN K. BALASUBRAMANIAN | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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File | Description | Size | Format | Access Settings | Version | |
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Wang_Hongyan.pdf | 11.58 MB | Adobe PDF | OPEN | None | View/Download |
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