Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/13667
Title: Molecular analysis of maternal diabetes induced changes in the developing neural tube
Authors: LIAO DONGMEI
Keywords: maternal diabetes, neural tube defects, forebrain, teratogen, amoeboid microglia/brain macrophage, cytokines
Issue Date: 23-Feb-2004
Source: LIAO DONGMEI (2004-02-23). Molecular analysis of maternal diabetes induced changes in the developing neural tube. ScholarBank@NUS Repository.
Abstract: In this study, we have analyzed molecular and morphological changes in the forebrain of E11.5 embryos from diabetic mice. The molecular bases for the forebrain malformations have been examined using various molecular markers by in situ hybridization and real time RT-PCR. The results suggest that altered expression of various signaling molecules involved in the dorsoventral patterning of forebrain is the major causative factor for the forebrain malformations observed in the embryos of diabetic mice. We have also analyzed whether the exposure of diabetic embryos to Cyclophosphamide, are linked to pathogenesis of neural tube defects (NTD) during development. This study reveals that maternal diabetes aggravates the teratogen-induced inflammation by the increased number of AM/BM and the enhanced expression of inflammatory cytokines such as TNF-ai?!and TGF-??1 in the developing neural tube.
URI: http://scholarbank.nus.edu.sg/handle/10635/13667
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