Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/13654
Title: Database development and mechanistic study of traditional Chinese medicine by computer
Authors: WANG JIFENG
Keywords: TCM, Database, SVM, INVDOCK, Prescription Formulation
Issue Date: 26-Feb-2004
Source: WANG JIFENG (2004-02-26). Database development and mechanistic study of traditional Chinese medicine by computer. ScholarBank@NUS Repository.
Abstract: Traditional Chinese medicine (TCM) has been used in the treatment of a variety of diseases and is recognized as a valuable alternative to conventional medicine. In this work, several computer-based methods are employed to study TCM. Firstly, we developed a new database, Traditional Chinese Medicine Information Database TCMID, to provide, in an integrated manner, comprehensive information about all aspects of TCM including prescription formula, constituent herbs, known herbal ingredients and their molecular actions. Secondly, the principle of TCM prescription formulation was studied by a statistical method, Support Vector Machine (SVM). The results indicate the ability of SVM on recognition of effective TCM formulas. Thirdly, we studied medicinal herbs by a ligand-protein inverse-docking program INVDOCK. The results show the potential of this approach in exploration of the molecular mechanism of medicinal herbs.
URI: http://scholarbank.nus.edu.sg/handle/10635/13654
Appears in Collections:Master's Theses (Open)

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