Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/136059
Title: BEDAQUILINE TARGETS THE EPSILON SUBUNIT OF MYCOBACTERIAL F-ATP SYNTHASE
Authors: SUBHASHRI KUNDU
Keywords: TMC207, Bedaquiline, target, epsilon, tuberculosis, subunit
Issue Date: 6-Feb-2017
Source: SUBHASHRI KUNDU (2017-02-06). BEDAQUILINE TARGETS THE EPSILON SUBUNIT OF MYCOBACTERIAL F-ATP SYNTHASE. ScholarBank@NUS Repository.
Abstract: The tuberculosis drug Bedaquiline inhibits mycobacterial F-ATP synthase by binding to its c subunit. Using purified ε subunit of the synthase and spectroscopy we previously demonstrated that the drug interacts with this protein near its unique tryptophan residue. Here we show that replacement of ε’s tryptophan with alanine resulted in Bedaquiline hyper susceptibility of the bacteria. Overexpression of wild type ε subunit caused resistance. These results suggest that the drug also targets the ε subunit.
URI: http://scholarbank.nus.edu.sg/handle/10635/136059
Appears in Collections:Ph.D Theses (Open)

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