Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/135739
DC Field | Value | |
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dc.title | DEVELOPMENT OF TWO-PHOTON SMALL-MOLECULE PROBES FOR SPECIFIC ENZYMES | |
dc.contributor.author | QIAN LINGHUI | |
dc.date.accessioned | 2017-05-24T18:00:17Z | |
dc.date.available | 2017-05-24T18:00:17Z | |
dc.date.issued | 2017-01-11 | |
dc.identifier.citation | QIAN LINGHUI (2017-01-11). DEVELOPMENT OF TWO-PHOTON SMALL-MOLECULE PROBES FOR SPECIFIC ENZYMES. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/135739 | |
dc.description.abstract | Enzymes are essential to sustain life and they also play critical roles in the development of disease and therapeutic processes. Two-photon small-molecule probes (TSMPs) producing specific fluorescent signals towards target biomolecules are demonstrated to be advantageous in tissue and in vivo imaging. However, currently available TSMPs only cover a small portion of enzymes in spite of the distinctive advantages of two-photon fluorescence microscopy (TPFM). With knowledge of existing substrates/inhibitors for most enzymes, we are inspired to design TSMPs either mimicking the substrate or containing an inhibitor-moiety for recognition. In addition to produce “Turn-On” two-photon signals, we are also trying to address issues including the selectivity, sensitivity and spatiotemporal resolutions. And our strategies are also promising to be applied to other enzymes. | |
dc.language.iso | en | |
dc.subject | two-photon, small-molecule probe, enzyme detection | |
dc.type | Thesis | |
dc.contributor.department | CHEMISTRY | |
dc.contributor.supervisor | YAO SHAO QIN | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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QianLH.pdf | 12.07 MB | Adobe PDF | OPEN | None | View/Download |
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