Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/135465
Title: MELT SPHERONIZATION - DIRECT ROTARY SHAPING PROCESS FOR HOT MELT EXTRUDATES
Authors: THIN YU TUN
Keywords: Melt spheronization, Direct shaping, Hot melt extrusion, Melt Rheology, Melt Pellets, Multiparticulates
Issue Date: 16-Sep-2016
Source: THIN YU TUN (2016-09-16). MELT SPHERONIZATION - DIRECT ROTARY SHAPING PROCESS FOR HOT MELT EXTRUDATES. ScholarBank@NUS Repository.
Abstract: Pellets are the primary units of multiparticulate pharmaceutical dosage forms, both as immediate or sustained release pellets. Due to their uniform shape and size, pellets offer biopharmaceutical advantages in terms of more even and predictable distribution and transportation in the gastrointestinal tract, which is fairly independent of the nutritional intake. Hot melt extrusion (HME) has emerged as an alternative “platform technology” for solid dosage form development in recent years. HME requires fewer processing steps or major downstream processing equipment and this clearly offers major advantages to new drug product development. HME with spheronization (collectively to be referred as melt spheronization) method can be used for developing solid dispersion pellets of poorly water-soluble drugs for solubility enhancement. Therefore, the objective of the study is to understand influence of formulation variables on the viscoelastic properties and impact of spheronization conditions on the physicomechanical properties of melt pellets. The study also aims to provide insights on the viability of spheroid development using the hot melt extrusion coupled with direct rotary shaping technique.
URI: http://scholarbank.nus.edu.sg/handle/10635/135465
Appears in Collections:Ph.D Theses (Open)

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