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Title: | LYMPHATIC SYSTEM: A DOUBLE-EDGED SWORD IN THERAPEUTIC INTERVENTION | Authors: | YEO KIM PIN | Keywords: | lymphangiogenesis, lymph node, lymphadenectomy, cancer, atherosclerosis, inflammation | Issue Date: | 5-Aug-2016 | Citation: | YEO KIM PIN (2016-08-05). LYMPHATIC SYSTEM: A DOUBLE-EDGED SWORD IN THERAPEUTIC INTERVENTION. ScholarBank@NUS Repository. | Abstract: | Lymphatic system regulates tissue fluid homeostasis, immunosurveillance and lipid transport. In cancer, lymphadenectomy is a common practice. However, randomized prospective trials have failed to provide convincing clinical benefits. Using a spontaneous melanoma model, we showed that lymphadenectomy not only enhanced growth of primary tumors and tumor-associated blood vessels, but also promoted cancer cell dissemination and metastatic outgrowth. These consequences were reversed by anti-inflammatory drug treatments. Our findings suggested that lymphadenectomy may only be beneficial if used in combination with anti-inflammatory agents. On the other hand, in chronic inflammatory atherosclerosis, lymphatic vessels were remodelled. This was accompanied by infiltration of VEGF-C-expressing macrophages and angiogenesis. This observation was ameliorated by treatment with cholesterol-lowering drug. Collectively, we showed that lymphatic vessels were altered during inflammation (atherosclerosis) and modulating lymphatic system (lymphadenectomy) could also affect inflammation. This indicated that inflammation appears to be the key player and intervention targeting inflammation could potentially be beneficial. | URI: | http://scholarbank.nus.edu.sg/handle/10635/135279 |
Appears in Collections: | Ph.D Theses (Open) |
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