Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/13511
Title: A pharmacoeconomic evaluation of bisphosphonates in the management of postmenopausal osteoporosis in Singapore
Authors: HING WEE CHUAN
Keywords: Postmenopausal Osteoporosis, Diphosphonates, Bone Mineral Density, Pharmacoeconomics, Femoral Neck fractures, Spinal fractures
Issue Date: 23-Oct-2003
Source: HING WEE CHUAN (2003-10-23). A pharmacoeconomic evaluation of bisphosphonates in the management of postmenopausal osteoporosis in Singapore. ScholarBank@NUS Repository.
Abstract: Objective : The objective of this thesis is to elucidate the most appropriate bisphosphonate for prevention of hip and vertebral fractures in postmenopausal women, taking local costing factors and fracture rates into consideration.Methods : Data from available literature is pooled for the various bisphosphonates in order to determine their safety and efficacy profile. Results of the pooled analysis is applied to pharmacoeconomic models, allowing for comparing between the agents to determine the most cost effective bisphosphonate.Results : From the meta-analyses, alendronate was the most efficacious agent for improving vertebral and femoral neck bone mineral density. Insufficient data were available for tiludronate, clodronate, pamidronate and ibandronate to recommend for long duration of usage. Etidronate was found to be the most cost effective bisphosphonate when compared for either lumbar or femoral neck bone mineral density, even with various sensitivity analyses applied.Conclusion : The analyses suggests etidronate to be the choice of treatment for prevention of osteoporotic fractures and alendronate as an alternative for patients who can afford its higher price.
URI: http://scholarbank.nus.edu.sg/handle/10635/13511
Appears in Collections:Master's Theses (Open)

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