Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/134940
Title: FLUORESCENT LIGHT-UP PROBES WITH AGGREGATION-INDUCED EMISSION (AIE) CHARACTERISTICS
Authors: ZHANG RUOYU
Keywords: Aggregation-induced Emission, Fluorescence probes, Biosensing, turn-on probes, AIE-peptide
Issue Date: 8-Aug-2016
Source: ZHANG RUOYU (2016-08-08). FLUORESCENT LIGHT-UP PROBES WITH AGGREGATION-INDUCED EMISSION (AIE) CHARACTERISTICS. ScholarBank@NUS Repository.
Abstract: Fluorescent biosensors are powerful and indispensable tools for understanding biological activities, monitoring biological processes and detecting disease markers. Recently, intense research interests have been attracted to develop probes based on fluorogens with aggregation-induced emission characteristics (AIE). Unlike traditional organic fluorogens suffering from aggregation-caused quenching (ACQ), the intrinsic AIE characteristics facilitate the construction of fluorescence turn-on probes with higher sensitivity. However, the majority of the early AIE probes were designed based on electrostatic or hydrophobic interactions, which lacked specificity. In this thesis, AIE-peptide based fluorescent light-up probes have been designed and developed for specific biosensing and bioimaging applications. After demonstration of a general strategy for probe design, a specific light-up probe was designed for chymase detection and enzyme activity study. In addition, an AIE-peptide conjugate was designed for transferrin receptor (TfR) imaging and related photodynamic therapy (PDT) study. Finally, a specific AIE probe was developed for monitoring of cell apoptosis.
URI: http://scholarbank.nus.edu.sg/handle/10635/134940
Appears in Collections:Ph.D Theses (Open)

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