Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/134929
Title: A STUDY ON SURFACE ROUGHNESS OF LACTOSE CARRIER PARTICLES
Authors: TAN MEI JIN, BERNICE
Keywords: dry powder inhaler, optical profilometry, aerodynamic size, fluid-bed coating, roller compaction, Raman spectroscopy
Issue Date: 18-Aug-2016
Citation: TAN MEI JIN, BERNICE (2016-08-18). A STUDY ON SURFACE ROUGHNESS OF LACTOSE CARRIER PARTICLES. ScholarBank@NUS Repository.
Abstract: Carrier surface roughness is an important physical characteristic which critically influences the aerosolization of micronized drug particles in carrier-based dry powder inhaler (DPI) formulations. This research work attempted to address several important aspects in the development of improved DPI formulations by surface roughening of lactose carrier particles. In the first part of the work, reliable criteria for roughness measurement were defined, particularly the filtering wavelength in image processing, image size and sample size. Roughened carrier particles were then prepared using both fluid-bed coating and roller compaction. The roughened carriers produced using both methods, when incorporated into DPI formulations containing a micronized drug, showed significant improvement in the fine particle fractions. Studies using Raman spectral mapping showed that the surface distribution of drug particles/agglomerates was influenced by carrier surface roughness. Overall, these findings can aid formulation scientists in refining the selection criteria for carriers, especially in terms of their surface characteristics.
URI: http://scholarbank.nus.edu.sg/handle/10635/134929
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
TanMJB_2016.pdf5.61 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

94
checked on Dec 6, 2018

Download(s)

128
checked on Dec 6, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.