Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/134684
Title: CORD-STEM CELL APPLICATION FOR REGENERATION ENHANCEMENT IN PORCINE MODEL
Authors: LIEW XUAN KAI JUSTIN
Keywords: liver regeneration, stem cell, cord-lining
Issue Date: 3-Aug-2016
Source: LIEW XUAN KAI JUSTIN (2016-08-03). CORD-STEM CELL APPLICATION FOR REGENERATION ENHANCEMENT IN PORCINE MODEL. ScholarBank@NUS Repository.
Abstract: Stem cells are known for their ability to repair damaged tissue. Earlier studies showed Cord Lining Epithelial Cells (CLEC) survived in immunologically competent specimens and could be differentiated into functioning hepatocyte-like cells (HLC). 16 Yorkshire-Dutch Landrace pigs were selected in this initial study to develop CLEC as a treatment modality for liver failure. 50% hepatectomy was performed to simulate the liver insufficiency disease model. After surgery, the control arm was transplanted with saline scaffold while the study arm was transplanted with HLC scaffold. The pigs were studied for post-operative 3 weeks. Liver biopsy showed minimal and non-specific reactions in both groups. Immunohistochemistry staining showed HLC survived for 3 weeks after transplantation. This study showed that HLC poses insignificant toxicity in a xeno-transplantation model. The unique cell delivery method showed superficial cell attachment. While a positive trend was developing, HLC did not display statically significant effect in accelerating liver regeneration post-transplantation.
URI: http://scholarbank.nus.edu.sg/handle/10635/134684
Appears in Collections:Master's Theses (Open)

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