Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/134570
Title: THE ROLE OF COLONIC ANTIMICROBIAL PEPTIDES IN HUMAN BLASTOCYSTIS INFECTIONS
Authors: JOHN ANTHONY D. YASON
Keywords: Blastocystis, subtype, antimicrobial peptides, resistance, innate immune response
Issue Date: 18-Aug-2016
Source: JOHN ANTHONY D. YASON (2016-08-18). THE ROLE OF COLONIC ANTIMICROBIAL PEPTIDES IN HUMAN BLASTOCYSTIS INFECTIONS. ScholarBank@NUS Repository.
Abstract: Blastocystis is a common eukaryotic organism found in the human gut. The study explores the roles of antimicrobial peptides (AMPs) expressed in the colon when Blastocystis infect humans. AMPs are elements of the innate immunity and contribute in the protection of the intestinal mucosa from microbial invasion. A drug assay was used to identify the susceptibility of Blastocystis to three colonic AMPs (cathelicidin/LL-37, human beta-defensin 1 and human beta-defensin 2). LL-37 was found to have broad activity on various Blastocystis isolates. However, Blastocystis subtype (ST) 7 isolates showed relative resistance against the peptide. This is due to the ST’s ability to secrete proteases and alter the surrounding pH. The thicker surface coat of ST7 isolates may also confer resistance against LL-37 killing. The parasite can induce LL-37 gene expression in intestinal cells. Results in this study suggest a significant role for AMPs, particularly LL-37, in human Blastocystis infections.
URI: http://scholarbank.nus.edu.sg/handle/10635/134570
Appears in Collections:Ph.D Theses (Open)

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