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https://scholarbank.nus.edu.sg/handle/10635/134462
DC Field | Value | |
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dc.title | N-HETEROCYCLIC CARBENE CATALYZED ASYMMETRIC ANNULATIONS VIA AZOLIUM ENOLATES AND HOMOENOLATES | |
dc.contributor.author | WANG MIN | |
dc.date.accessioned | 2016-12-31T18:02:08Z | |
dc.date.available | 2016-12-31T18:02:08Z | |
dc.date.issued | 2016-08-05 | |
dc.identifier.citation | WANG MIN (2016-08-05). N-HETEROCYCLIC CARBENE CATALYZED ASYMMETRIC ANNULATIONS VIA AZOLIUM ENOLATES AND HOMOENOLATES. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/134462 | |
dc.description.abstract | As one of the hottest research areas in organocatalysis, N-Heterocyclic Carbene (NHC) catalysis has been developed into a very powerful tool for asymmetric annulation reactions. This thesis describes my efforts during my PhD studies that focus on NHC catalysis to develop different sizes of ring compounds. Chapter 1 provides a detailed review of the recent development of NHC-catalyzed asymmetric annulations via azolium enolates and homoenolates. Chapter 2 presents an interesting work about NHC-catalyzed divergent annulation of enals with heterocyclic enones, affording either ε-lactones or spiro-heterocycles in good diastereoselectivity and enantioselectivity. Chapter 3 demonstrates highly efficient and diastereodivergent aza-Dies-Alder reactions using either NHC or chiral amine as the catalysts, accessing both diastereomers of a series of benzofuran-fused δ-lactams and dihydropyridines in nearly perfect enantioselectivity. Chapter 4 introduces the kinetic resolution of 1,1'-spirobiindane-7,7'-diol via enantioselective acylation. The spiro cyclic diol is a very useful structure, which can be employed as chiral catalysts and ligands. | |
dc.language.iso | en | |
dc.subject | NHC, ANNULATIONS, ENOLATES, HOMOENOLATES, ASYMMETRIC, ORGANOCATALYSIS | |
dc.type | Thesis | |
dc.contributor.department | CHEMISTRY | |
dc.contributor.supervisor | ZHAO YU | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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