Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/134453
Title: A MOLECULAR STUDY ON SOME GENES KNOWN TO BE RELATED TO DISUSE MUSCLE ATROPHY IN THE AFRICAN LUNGFISH, PROTOPTERUS ANNECTENS, DURING THREE PHASES OF AESTIVATION
Authors: ONG LI YING JASMINE
Keywords: disuse muscle atrophy, aestivation, ppargc-1a, mstn, fbxo32, sod
Issue Date: 30-May-2016
Source: ONG LI YING JASMINE (2016-05-30). A MOLECULAR STUDY ON SOME GENES KNOWN TO BE RELATED TO DISUSE MUSCLE ATROPHY IN THE AFRICAN LUNGFISH, PROTOPTERUS ANNECTENS, DURING THREE PHASES OF AESTIVATION. ScholarBank@NUS Repository.
Abstract: African lungfishes (Protopterus spp) can aestivate without food and water for many years. Disuse muscle atrophy is not prominent during aestivation, and lungfish aroused from aestivation can struggle out of the cocoon. Hence, there could be a tight regulation of genes/proteins involved in muscle formation and muscle degradation, and in oxidative defense as disuse muscle atrophy is partially attributable to oxidative damages, in the aestivating fish. This study aimed to sequence certain genes known to be involved in muscle formation or muscle degradation from the skeletal muscle of Protopterus annectens, and to determine the effects of aestivation on their mRNA expression levels and protein abundances. Efforts were also made to determine effects of aestivation on (1) the mRNA expression levels and protein abundances of genes/proteins involved in oxidative defense, (2) their specific activities and (3) the levels of several oxidative stress markers in the skeletal muscle.
URI: http://scholarbank.nus.edu.sg/handle/10635/134453
Appears in Collections:Ph.D Theses (Open)

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