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|Title:||Serum estradiol 17β and serum human chorionic gonadotropin in patients with hydatidiform moles|
|Citation:||Dawood, M.Y., Ratnam, S.S., Teoh, E.S. (1974). Serum estradiol 17β and serum human chorionic gonadotropin in patients with hydatidiform moles. American Journal of Obstetrics and Gynecology 119 (7) : 904-910. ScholarBank@NUS Repository.|
|Abstract:||Serum estradiol 17β (E2) was measured by radioimmunoassay in cases cases of unaborted hydatidiform mole, 2 cases of aborted hydatidiform mole, and 103 cases of normal pregnancy between the 6th and 25th weeks of gestation. The antibody used was a specific antiserum raised in sheep against 17β estradiol 6 (O carboxymethyl) oxime coupled to bovine serum albumin. Concentrations of serum total E2 in cases of intact molar pregnancies ranged from 4.2 to 112.3 ng per ml with a mean ± standard error of the mean (SEM) of 35.7 ± 4.6 ng per ml while the corresponding range for unconjugated E2 was 2.4 to 76.3 ng per ml with a mean ± SEM of 22.6 ± 3.0 ng per ml. Serum total E2 values in the patients with aborted moles were 2.2 and 2.6 ng per ml. Serum E2 was significantly higher in patients with intact molar pregnancies than in those with normal pregnancies of corresponding gestations (p < 0.005). The mean ± SEM of serum unconjugated E2 in 12 cases of intact moles with theca lutein cysts was 31.4 ± 6.0 ng per ml and was significantly higher than the corresponding value of 17.0 ± 2.6 ng per ml in 19 cases of intact moles without theca lutein cysts. There was no significant correlation between serum E2 and uterine size, but there was a significant correlation between serum E2 and serum human chorionic gonadotropin in molar pregnancies (coefficient of correlation r = 0.494). The value of serum E2 as a possile endocrine diagnostic index in addition to other hormone assays in patients with hydatidiform mole is discussed. Possible explanations for the elevated serum E2 findings in molar gestation are also put forward.|
|Source Title:||American Journal of Obstetrics and Gynecology|
|Appears in Collections:||Staff Publications|
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