Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0014-5793(99)01329-0
Title: S. pombe Pbh1p: An inhibitor of apoptosis domain containing protein is essential for chromosome segregation
Authors: Rajagopalan, S.
Balasubramanian, M.K. 
Keywords: Apoptosis
BIR domain
Fission yeast
Mitosis
pbh1
Issue Date: 22-Oct-1999
Citation: Rajagopalan, S., Balasubramanian, M.K. (1999-10-22). S. pombe Pbh1p: An inhibitor of apoptosis domain containing protein is essential for chromosome segregation. FEBS Letters 460 (1) : 187-190. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-5793(99)01329-0
Abstract: Proteins containing the baculovirus inhibitor of apoptosis repeats (BIR domains) have been identified in a wide range of species. BIR domain containing proteins are thought to inhibit caspases and thereby cause inhibition of apoptosis. A BIR domain containing protein has been recently identified by the Schizosaccharomyces pombe genome sequencing project. However, caspase-like proteins have not been found in yeasts, suggesting that the BIR domain containing proteins might play a fundamental role in cell regulation, in addition to their well-characterized role in inhibition of apoptosis. In this study, we have characterized Pbh1p, an S. pombe BIR domain containing protein. Construction and analysis of a null mutant in pbh1+ revealed that pbh1+ is essential for cell viability. Moreover, cells devoid of Pbh1p are defective in chromosome condensation and chromosome segregation. Thus, proper chromosome segregation requires the function of Pbh1p. Over-production of Pbh1p led to abnormalities in mitosis and cytokinesis, suggesting that the levels of Pbh1p are important for regulation of mitosis and cytokinesis. Copyright (C) 1999 Federation of European Biochemical Societies.
Source Title: FEBS Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/134134
ISSN: 00145793
DOI: 10.1016/S0014-5793(99)01329-0
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

23
checked on Jul 16, 2018

WEB OF SCIENCETM
Citations

27
checked on Jul 16, 2018

Page view(s)

32
checked on Jul 5, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.