Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/134128
Title: The Drosophila TGFα homolog Spitz acts in photoreceptor recruitment in the developing retina
Authors: Tio, M. 
Moses, K.
Keywords: Drosophila
EGF-receptor
Patterning
Retina
Spitz
Issue Date: Jan-1997
Source: Tio, M., Moses, K. (1997-01). The Drosophila TGFα homolog Spitz acts in photoreceptor recruitment in the developing retina. Development 124 (2) : 343-351. ScholarBank@NUS Repository.
Abstract: In vertebrates and Drosophila, the Epidermal Growth Factor Receptor (EGFR) signal transduction pathway is important in the regulation of cellular development. EGFR is bound by several activating ligands including Transforming Growth Factor-α in vertebrates, and its homolog Spitz in Drosophila. It has been shown that Spitz and EGFR act in the development of the Drosophila central nervous system and compound eye. Here we show that spitz function is required in developing ommatidia for the first cell recruitment step, and that Spitz pro-protein is expressed in the retinal neurons as they begin to differentiate. We propose a 'two-key' model for additive signal transduction from EGFR and other receptor tyrosine kinases, via the Ras pathway, in the developing eye.
Source Title: Development
URI: http://scholarbank.nus.edu.sg/handle/10635/134128
ISSN: 09501991
Appears in Collections:Staff Publications

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