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Abstract
Fasting serum gastrin was determined by radioimmunoassay with the Dianabot kit (Tokyo) in 81 Chinese subjects. The mean fasting serum gastrin level in 43 duodenal ulcer patients (73 pg/ml) was higher than that in 18 control subjects (57 pg/ml) though the difference did not reach statistical significance. These levels fall within the range in Caucasians. The findings support the hypothesis that impaired auto-regulation of gastrin release in patients with duodenal ulcer by low antral pH is a contributing factor in duodenal ulcer diathesis. The mean fasting level in 19 gastric ulcer patients (68 pg/ml) was also higher than in the control subjects, but not significantly so. The infrequency of hypergastrinaemia in these gastric ulcer patients is probably due to associated antral gastritis.
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Source Title
Singapore Medical Journal
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Date
1981
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Type
Article