Please use this identifier to cite or link to this item: https://doi.org/10.1016/0304-3940(84)90386-0
Title: Suppression of arterial pressure, heart rate and cardiac contractility following microinjection of kainic acid into the nucleus ambiguus of the rat
Authors: Chan, S.H.H.
Ong, B.T.
Wong, P.T.H. 
Issue Date: 1984
Source: Chan, S.H.H., Ong, B.T., Wong, P.T.H. (1984). Suppression of arterial pressure, heart rate and cardiac contractility following microinjection of kainic acid into the nucleus ambiguus of the rat. Neuroscience Letters 47 (1) : 57-62. ScholarBank@NUS Repository. https://doi.org/10.1016/0304-3940(84)90386-0
Abstract: In pentobarbital anesthetized rats, unilateral microinjection (500 ng) of the selective perikaryal excitotoxin, kainic acid, into the nucleus ambiguus promoted a significant suppression of arterial pressure, heart rate and cardiac contractility. The degree of such cardiovascular depression followed the order of heart contractility reduction (50.7%) > hypotension (28.9%) > bradycardia (20.8%) at the end of a 60-min postinjection period. We concluded that the nucleus ambiguus may exert its control on cardiac activities by both negative chronotropic and inotropic effects on the heart.
Source Title: Neuroscience Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/134006
ISSN: 03043940
DOI: 10.1016/0304-3940(84)90386-0
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