Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0169-328X(97)00191-5
Title: Regulation of anterior pituitary galanin gene expression by thyroid hormone
Authors: Hooi, S.C. 
Koenig, J.I.
Abraczinskas, D.R.
Kaplan, L.M.
Keywords: Galanin
Gene expression
Hypothalamus
Pituitary
Thyroid hormone
Issue Date: Nov-1997
Citation: Hooi, S.C., Koenig, J.I., Abraczinskas, D.R., Kaplan, L.M. (1997-11). Regulation of anterior pituitary galanin gene expression by thyroid hormone. Molecular Brain Research 51 (1-2) : 15-22. ScholarBank@NUS Repository. https://doi.org/10.1016/S0169-328X(97)00191-5
Abstract: Thyroid hormone is required for basal and estrogen-induced expression of anterior pituitary galanin. Steady-state anterior pituitary galanin mRNA levels decreased 6-fold in hypothyroid rats after 3 weeks of treatment. Similarly, hypothyroidism resulted in a 2.6-fold decrease in estrogen induction of galanin gene expression. The effect of thyroid hormone on anterior pituitary galanin gene expression appears to be exerted, at least in part, at the pituitary itself. Transient expression assays in GH3 cells suggest the involvement of transcriptional mechanisms in the regulation of galanin gene expression by thyroid hormone. A region between -41 and -132 bp upstream of the transcriptional start site confers thyroid hormone responsiveness to the galanin gene. Gel-mobility shift assays show specific binding of 'SPI-like' proteins in GH3 nuclear extracts to this region of the galanin gene. This binding was greatly enhanced by thyroid hormone.
Source Title: Molecular Brain Research
URI: http://scholarbank.nus.edu.sg/handle/10635/133993
ISSN: 0169328X
DOI: 10.1016/S0169-328X(97)00191-5
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

16
checked on Nov 13, 2018

WEB OF SCIENCETM
Citations

18
checked on Oct 22, 2018

Page view(s)

14
checked on Nov 8, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.