Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/133980
DC Field | Value | |
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dc.title | Targeting of liposomes via passively-adsorbed monclonal antibodies to human hepatocellular carcinoma cells in vitro | |
dc.contributor.author | Tan, L. | |
dc.contributor.author | Gregoriadis, G. | |
dc.date.accessioned | 2016-12-20T08:42:10Z | |
dc.date.available | 2016-12-20T08:42:10Z | |
dc.date.issued | 1990 | |
dc.identifier.citation | Tan, L., Gregoriadis, G. (1990). Targeting of liposomes via passively-adsorbed monclonal antibodies to human hepatocellular carcinoma cells in vitro. Asia Pacific Journal of Pharmacology 5 (3) : 219-222. ScholarBank@NUS Repository. | |
dc.identifier.issn | 02179687 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/133980 | |
dc.description.abstract | Small unilamellar vesicles (SUV) were coated with monoclonal antibodies RF-HCC1 (IgG1), RF-HCC2 (IgM) and MOPC 21 IgG1, which bind to surface antigens on Mahlavu cells, by passive adsorption. Adsorption values for the three antibodies were 35.1%, 51.6% and 12.2% respectively. On incubation of the liposomes containing the aqueous marker carbocyfluorescein (CF) with Mahlavu cells in vitro at 4°C, it was seen that binding of antibody and association of CF with cells took place in a biphasic manner with maximal binding occuring by 1 hour followed by a plateau phase. These results indicate that passively-adsorbed antibodies represent a rapid, conventient and effective method of ligand-mediated targeting of SUV to cells in vitro. | |
dc.type | Article | |
dc.contributor.department | PHARMACOLOGY | |
dc.description.sourcetitle | Asia Pacific Journal of Pharmacology | |
dc.description.volume | 5 | |
dc.description.issue | 3 | |
dc.description.page | 219-222 | |
dc.description.coden | APJPE | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
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