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|Title:||Simultaneous estimation of serum concentrations of dapsone, monoacetyldapsone, and pyrimethamine in Chinese men on maloprim for malaria prophylaxis using reversed-phase high performance liquid chromatography|
|Authors:||Lee, H.S. |
|Citation:||Lee, H.S., Ti, T.Y., Lee, P.S., Yap, C.L. (1985). Simultaneous estimation of serum concentrations of dapsone, monoacetyldapsone, and pyrimethamine in Chinese men on maloprim for malaria prophylaxis using reversed-phase high performance liquid chromatography. Therapeutic Drug Monitoring 7 (4) : 415-420. ScholarBank@NUS Repository.|
|Abstract:||A reversed-phase high performance liquid chromatography method was developed to simultaneously estimate serum concentrations of dapsone (DDS), monoacetyldapsone (MADDS), and pyrimethamine (PYR) in 34 young adult Chinese men after they had taken the sixth weekly dose of Maloprim for malaria prophylaxis. Serum concentrations of DDS, MADDS, and PYR after 24 h were (mean ± SEM) 374 ± 31.1, 310 ± 30.4, and 121 ± 7.9 ng/ml, respectively. The 72-h serum concentrations of DDS, MADDS, and PYR were (mean ± SEM) 134 ± 21.6, 115 ± 17.9, and 80 ± 7.2 ng/ml, respectively. Serum concentrations of DDS and MADDS in many subjects after 120 h were|
|Source Title:||Therapeutic Drug Monitoring|
|Appears in Collections:||Staff Publications|
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