Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/133979
Title: Simultaneous estimation of serum concentrations of dapsone, monoacetyldapsone, and pyrimethamine in Chinese men on maloprim for malaria prophylaxis using reversed-phase high performance liquid chromatography
Authors: Lee, H.S. 
Ti, T.Y. 
Lee, P.S.
Yap, C.L.
Issue Date: 1985
Source: Lee, H.S., Ti, T.Y., Lee, P.S., Yap, C.L. (1985). Simultaneous estimation of serum concentrations of dapsone, monoacetyldapsone, and pyrimethamine in Chinese men on maloprim for malaria prophylaxis using reversed-phase high performance liquid chromatography. Therapeutic Drug Monitoring 7 (4) : 415-420. ScholarBank@NUS Repository.
Abstract: A reversed-phase high performance liquid chromatography method was developed to simultaneously estimate serum concentrations of dapsone (DDS), monoacetyldapsone (MADDS), and pyrimethamine (PYR) in 34 young adult Chinese men after they had taken the sixth weekly dose of Maloprim for malaria prophylaxis. Serum concentrations of DDS, MADDS, and PYR after 24 h were (mean ± SEM) 374 ± 31.1, 310 ± 30.4, and 121 ± 7.9 ng/ml, respectively. The 72-h serum concentrations of DDS, MADDS, and PYR were (mean ± SEM) 134 ± 21.6, 115 ± 17.9, and 80 ± 7.2 ng/ml, respectively. Serum concentrations of DDS and MADDS in many subjects after 120 h were
Source Title: Therapeutic Drug Monitoring
URI: http://scholarbank.nus.edu.sg/handle/10635/133979
ISSN: 01634356
Appears in Collections:Staff Publications

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