Please use this identifier to cite or link to this item:
|Title:||Role of capsaicin sensitive nerves in epidermal growth factor effects on gastric mucosal injury and blood flow|
|Authors:||Kang, J.Y. |
|Keywords:||Calcitonin gene related peptide antagonist|
Epidermal growth factor
Gastric mucosal blood flow
Gastric mucosal injury
|Source:||Kang, J.Y., Teng, C.H., Chen, F.C., Wee, A. (1998). Role of capsaicin sensitive nerves in epidermal growth factor effects on gastric mucosal injury and blood flow. Gut 42 (3) : 344-350. ScholarBank@NUS Repository.|
|Abstract:||Backgrounds - Epidermal growth factor (EGF) and capsaicin protect against experimental gastric mucosal injury. Capsaicin exerts its gastroprotective effect by stimulating afferent neurones leading to release of calcitonin gene related peptide (CGRP) which causes gastric hyperaemia. EGF also causes gastric hyperaemia but whether it acts via capsaicin sensitive neurones is unknown. Aims - To assess the influence of: (1) capsaicin desensitisation on EGF effects on gastric mucosal injury and gastric mucosal blood flow; and (2) close arterial infusion of hCGRP8-37, a CGRP antagonist, on EGF effects on gastric mucosal blood flow. Methods - The absolute ethanol induced gastric mucosal injury model in the rat was used. Gastric mucosal damage was assessed by planimetry and light microscopy. Gastric mucosal blood flow was measured by laser Doppler flowmetry in a gastric chamber preparation. Results - Capsaicin desensitisation abolished the gastroprotective and gastric hyperaemic effects of EGF. Close arterial infusion of hCGRP8-37 antagonised the hyperaemic effect of both capsaicin and EGF. Conclusion - Results show that EGF may exert its gastroprotective and gastric hyperaemic effects via capsaicin sensitive afferent neurones.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 20, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.