Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0020-7292(98)00096-4
Title: The effects of long-term hormone-replacement therapy on coagulation, fibrinolysis and inhibitors in postmenopausal women
Authors: Koh, S.C.L. 
Dramusic, V. 
Shan Ratnam, S. 
Keywords: Long-term effects of HRT on hemostasis
Issue Date: 1-Sep-1998
Source: Koh, S.C.L., Dramusic, V., Shan Ratnam, S. (1998-09-01). The effects of long-term hormone-replacement therapy on coagulation, fibrinolysis and inhibitors in postmenopausal women. International Journal of Gynecology and Obstetrics 62 (3) : 279-285. ScholarBank@NUS Repository. https://doi.org/10.1016/S0020-7292(98)00096-4
Abstract: Objective: To study the long-term effects of hormone-replacement therapy (HRT). Methods: Twenty-one menopausal Chinese women who were currently on HRT were studied for the long-term effects of HRT on hemostasis. Another 21 age-matched healthy women not on HRT served as controls. Results: Enhanced thrombin generation was seen in women on long-term HRT. Antithrombin III (ATIII) antigen was significantly reduced but not its activity level and so was FVII. Elevated t-PA activity and u-PA antigen were seen with reduced t-PA antigen. Plasminogen activator inhibitor-1 (PAI-1) levels were significantly reduced together with D-dimer in HRT. Conclusions: Long-term HRT was associated with enhanced thrombin generation and countered by enhanced systemic t-PA activity suggesting an equilibrium state. There was no enhanced cardiovascular risk in long-term HRT as indicated by the observed reduction in t-PA antigen, PAI-1 and FVII levels. However, a larger prospective study is required to confirm these findings.
Source Title: International Journal of Gynecology and Obstetrics
URI: http://scholarbank.nus.edu.sg/handle/10635/133780
ISSN: 00207292
DOI: 10.1016/S0020-7292(98)00096-4
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