Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/133747
Title: The effect of loperamide on prostaglandin induced diarrhoea in rat and man
Authors: Karim, S.M.M.
Adaikan, P.G. 
Issue Date: 1977
Citation: Karim, S.M.M., Adaikan, P.G. (1977). The effect of loperamide on prostaglandin induced diarrhoea in rat and man. Prostaglandins 13 (2) : 321-331. ScholarBank@NUS Repository.
Abstract: Loperamide, a new antidiarrhoeal compound, effectively antagonised prostaglandin induced diarrhoea in adult healthy male volunteers and in patients undergoing pregnancy termination with prostaglandins. This compound is effective in inhibiting prostaglandin induced fluid accumulation in the small intestine in rats. Loperamide also blocked smooth muscle stimulating action of prostaglandin, acetylcholine and histamine on gastrointestinal smooth muscle preparations from several laboratory animals.
Source Title: Prostaglandins
URI: http://scholarbank.nus.edu.sg/handle/10635/133747
ISSN: 00906980
Appears in Collections:Staff Publications

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