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|Title:||Prostaglandin 15-hydroxydehydrogenase activity in human penile corpora cavernosa and its significance in prostaglandin-mediated penile erection|
|Authors:||Roy, A.C. |
|Citation:||Roy, A.C., Adaikan, P.G., Sen, D.K., Ratnam, S.S. (1989). Prostaglandin 15-hydroxydehydrogenase activity in human penile corpora cavernosa and its significance in prostaglandin-mediated penile erection. British Journal of Urology 64 (2) : 180-182. ScholarBank@NUS Repository.|
|Abstract:||Prostaglandins may be involved in human penile erection and erectile failure. To evaluate the possible role of prostaglandin metabolism in the penile tissue, the activity of nicotinamide adenine dinucleotide-dependent prostaglandin 15-hydroxydehydrogenase was assayed in the corpora cavernosa of the human penis. Km values (mean ± SD) of the enzyme for PGE 1, PGE 2 and PGF(2α) were 60.1 ± 4.2, 17.7 ± 1.5 and 16.1 ± 1.2 μM respectively; Vmax values (mean ± SD) were 0.219 ± 0.062, 0.510 ± 0.012 and 0.424 ± 0.007 nmol/min/mg protein respectively. The implications of these findings in the erectile process are discussed.|
|Source Title:||British Journal of Urology|
|Appears in Collections:||Staff Publications|
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