Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/133679
Title: Prostaglandins, not cyclic GMP, inhibit oxytocinase isoenzymes from human amniotic fluid in vitro
Authors: Roy, A.C.C. 
Yeang, M.
Tan, S.M.
Kottegoda, S.R.
Ratnam, S.S. 
Issue Date: Aug-1985
Source: Roy, A.C.C., Yeang, M., Tan, S.M., Kottegoda, S.R., Ratnam, S.S. (1985-08). Prostaglandins, not cyclic GMP, inhibit oxytocinase isoenzymes from human amniotic fluid in vitro. Prostaglandins 30 (2) : 255-261. ScholarBank@NUS Repository.
Abstract: Two isoenzymes of oxytocinase (EC 3.4.11.3) activity were fractionated from human amniotic fluid samples between the 14th and 22nd weeks of gestation by Ultrogel acrylamide-agarose gel filtration and partially characterized. The isoenzymes were competitively inhibited by PGE1, PGE2 and PGF2α more at pH 6.2 than at pH 6.8, whereas cyclic GMP (cGMP) and its 8-bromo derivative had no effect at either pH. The implications of these findings are discussed and it is suggested that since the activity of amniotic fluid oxytocinases is very low or minimal at or near term, inhibition of these by prostaglandins may not have physiological significance in the initiation of human parturition. © 1985.
Source Title: Prostaglandins
URI: http://scholarbank.nus.edu.sg/handle/10635/133679
ISSN: 00906980
Appears in Collections:Staff Publications

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