Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/13362
DC Field | Value | |
---|---|---|
dc.title | Investigations on keloid pathogenesis and therapy | |
dc.contributor.author | ANANDAROOP MUKHOPADHYAY | |
dc.date.accessioned | 2010-04-08T10:32:21Z | |
dc.date.available | 2010-04-08T10:32:21Z | |
dc.date.issued | 2007-10-30 | |
dc.identifier.citation | ANANDAROOP MUKHOPADHYAY (2007-10-30). Investigations on keloid pathogenesis and therapy. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/13362 | |
dc.description.abstract | Keloid scars are a result of an aberration in the normal wound healing prcoess, and are characterized by overabundant collagen/ECM deposition. Several treatment modalities have been explored but none of the treatments are effective. In spite of the large number of growth factors, cytokines and chemokines that have been studied and are now known to play a role in its pathogenesis, the precise pathobiology leading to this scar formation remains largely unknown. Thus to identify new targets for therapeutic intervention, it is imperative to identify key modulators which are aberrantly expressed in keloids and to understand and assess the role of these modulators towards this fibrotic phenotype. In this study, activin-A, syndecan-2, fibroblast growth factor -2 and the stem cell factor/c-Kit system were all identified and demonstrated to play an important role in keloid pathogenesis and the effects of these growth factors was shown to be modulated by epithelial-mesenchymal interactions. Finally having identified these key targets, naturally occurring antagonists like follistatin and decorin and synthetic drugs like Gleevec were explored as potential therapeutic agents for keloid scars. | |
dc.language.iso | en | |
dc.subject | Keloid Scar, Epithelial-Mesenchymal Interactions, Activin-A, Proteoglycans, Stem cell factor, Gleevec | |
dc.type | Thesis | |
dc.contributor.department | PHARMACY | |
dc.contributor.supervisor | CHAN SUI YUNG | |
dc.contributor.supervisor | PHAN TOAN THANG | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
uploaded thesis.pdf | 4.1 MB | Adobe PDF | OPEN | None | View/Download |
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.