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https://scholarbank.nus.edu.sg/handle/10635/133610
DC Field | Value | |
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dc.title | Subcutaneously administered recombinant human β-interferon in the treatment of chronic hepatitis B virus infection | |
dc.contributor.author | Guan, R. | |
dc.contributor.author | Yeoh, K.G. | |
dc.contributor.author | Yap, I. | |
dc.contributor.author | Kang, J.Y. | |
dc.contributor.author | Wee, A. | |
dc.contributor.author | Smith, R. | |
dc.date.accessioned | 2016-12-20T08:38:03Z | |
dc.date.available | 2016-12-20T08:38:03Z | |
dc.date.issued | 1996 | |
dc.identifier.citation | Guan, R., Yeoh, K.G., Yap, I., Kang, J.Y., Wee, A., Smith, R. (1996). Subcutaneously administered recombinant human β-interferon in the treatment of chronic hepatitis B virus infection. Alimentary Pharmacology and Therapeutics 10 (5) : 807-814. ScholarBank@NUS Repository. | |
dc.identifier.issn | 02692813 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/133610 | |
dc.description.abstract | Background: Treatment of chronic replicative hepatitis B virus (HBV) infection is aimed at stopping viral replication and preventing the development of chronic liver disease. β-Interferon treatment has been less well studied than α-interferon. Methods: The efficacy and tolerability of a 6-month course of subcutaneously administered human recombinant β-interferon (rINF-β(ser)) was studied and the results of a low-dose regime compared with a high-dose regime. Twenty patients (17 men and three women), aged 24-54 years, with chronic hepatitis B virus infection (all hepatitis B surface antigen-positive with detectable HBV-DNA in their sera for at least 3 months prior to therapy) were randomized into two treatment groups of 10 patients each. The low-dose group received 6 x 106 U/dose and the high-dose group received 30 x 106 U/dose, both groups receiving their respective doses three times a week initially for 1 month and continuing for a total of 6 months. Results: The treatment was well tolerated in both groups. None of the patients required dosage reduction or cessation of treatment because of side-effects. HBV-DNA decreased in all patients during treatment, demonstrating the anti-viral efficacy of rINF-β(ser), and was undetectable in 20 and 40% of patients receiving low-dose and high-dose regimes, respectively, at the end of 6 months treatment (P = N.S.). One year after completion of treatment, HBV-DNA was undetectable in 50 and 30% of patients in the low-dose and high-dose groups, respectively (P = N.S.). However, only one patient achieved seroconversion with loss of the hepatitis B surface antigen and appearance of an antihepatitis B 'e' antigen at the end of 18 months. Conclusion: This study shows that subcutaneously administered rINF-β(ser) is well tolerated, but the optimal dose and duration of treatment still needs to be defined by further studies. | |
dc.type | Article | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | PATHOLOGY | |
dc.description.sourcetitle | Alimentary Pharmacology and Therapeutics | |
dc.description.volume | 10 | |
dc.description.issue | 5 | |
dc.description.page | 807-814 | |
dc.description.coden | APTHE | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
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