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|Title:||Radioimmunoassay of human growth hormone|
|Authors:||Cheah, J.S. |
|Source:||Cheah, J.S., Nakhoda, A.H. (1974). Radioimmunoassay of human growth hormone. Singapore Medical Journal 15 (2) : 110-114. ScholarBank@NUS Repository.|
|Abstract:||Radioimmunoassay of human growth hormone was carried out using the human growth hormone (HGH) 125 Imusay (Abbott Laboratories) this procedure being based on the solid phase radioimmunoassay technique. In 10 normal adult males, the mean fasting serum growth hormone was 9.2 ng/ml. (standard deviation: 5.7; range : 1.2 to 18.1 ng/ml.). Following insulin hypoglycemia, the mean peak serum growth hormone was 38.1 ng./ml. (standard deviation: 28.9; range : 7.6 to 108 ng./ml). In 6 patients with hypopituitarism, the mean fasting serum growth hormone was 2.5 ng./ml. (standard deviation: 1.4; range : 1.1 to 4.0 ng./ml.); following insulin hypoglycemia the mean peak serum growth hormone was 2.5 ng./ml. (standard deviation: 1.5; range : 1.1 to 4.4 ng./ml). In a further 6 normal male controls the mean fasting serum growth hormone was 7.8 ng./ml.; following an oral glucose tolerance test the mean serum growth fell to 1.3 ng./ml. In 5 cases of acromegaly, the mean fasting serum growth hormone was 82.6 ng./ml. (range : 45 to 190 ng./ml.). In one case, the serum growth hormone was partially suppressed by glucose while in the other 4 cases there was a paradoxical rise. The HGH 125 Imusay provides a relatively simple procedure for the radioimmunoassay of human growth hormone; the results obtained correlate very well with the clinical state of the patients. (16 references.)|
|Source Title:||Singapore Medical Journal|
|Appears in Collections:||Staff Publications|
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