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|Title:||Immunogenetics of nasopharyngeal carcinoma|
|Authors:||Chan, S.H. |
|Source:||Chan, S.H., Simons, M.J. (1977). Immunogenetics of nasopharyngeal carcinoma. Annals of the Academy of Medicine Singapore 6 (4) : 342-346. ScholarBank@NUS Repository.|
|Abstract:||The high incidence of nasopharyngeal carcinoma (NPC) among Chinese and Chinese-related peoples compared to other populations in the world suggests a prominent genetic element. There is also good evidence indicating that the ability to mount an immune response against an antigen is genetically controlled, in both experimental animals and in man. NPC patients have impairment of general cell-mediated immune function, abnormally high antibody responses to Epstein Barr viral antigens and high antinuclear factors. EB viral (EBV) genome has also been found in the NPC cells themselves. The HLA association in NPC appears to be with haplotypes suggesting the involvement of a whole region on chromosome 6. Different HLA haplotypes are associated with different subgroups of NPC. It is also suggested that there are NPC disease-associated (DA) genes which are included in that region of the chromosome and hence the HLA association. Some of the NPC DA genes associated with HLA may be involved with the regulation of immune responses. The high antibody levels to EBV antigens could then be explained by constant antigenic stimulation due to the failure of termination of EBV infection. (Pantazopoulos - Athens)|
|Source Title:||Annals of the Academy of Medicine Singapore|
|Appears in Collections:||Staff Publications|
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