Please use this identifier to cite or link to this item: https://doi.org/10.1002/ijc.2910180202
Title: Impaired general cell mediated immune functions in vivo and in vitro in patients with nasopharyngeal carcinoma
Authors: Chan, S.H. 
Chew, T.S.
Goh, E.H.
Simons, M.J.
Shanmugaratnam, K. 
Issue Date: 1976
Source: Chan, S.H., Chew, T.S., Goh, E.H., Simons, M.J., Shanmugaratnam, K. (1976). Impaired general cell mediated immune functions in vivo and in vitro in patients with nasopharyngeal carcinoma. International Journal of Cancer 18 (2) : 139-144. ScholarBank@NUS Repository. https://doi.org/10.1002/ijc.2910180202
Abstract: General cell mediated immune (CMI) functions in NPC patients were investigated by the in vivo Mantoux and in vitro lymphocyte response to PHA assays. Thirty eight (50%) of 76 untreated NPC patients were hyporesponsive in the Mantoux assay compared to 27 (25%) of 110 control patients. Forty three (65.2%) of 66 untreated NPC patients also showed lymphocyte hyporesponsiveness to PHA compared to 15 (15.5%) of 97 control patients. Combined deficiencies were observed in 35 (42.2%) of 83 NPC patients compared to only 2 (3.3%) of 61 control patients. No difference in the frequency of immunodeficiency was observed between 'early' and 'late' disease patients. CMI functions of treated 'remission' NPC patients were found to be impaired to the same extent as those of untreated NPC patients.
Source Title: International Journal of Cancer
URI: http://scholarbank.nus.edu.sg/handle/10635/133250
ISSN: 00207136
DOI: 10.1002/ijc.2910180202
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