Please use this identifier to cite or link to this item:
|Title:||Oncogenic potential of the RUNX gene family: 'Overview'|
Heterodimeric transcription factor
Leukemia, gastric cancer
|Source:||Ito, Y. (2004-05-24). Oncogenic potential of the RUNX gene family: 'Overview'. Oncogene 23 (24) : 4198-4208. ScholarBank@NUS Repository. https://doi.org/10.1038/sj.onc.1207755|
|Abstract:||Runt-related (RUNX) gene family is composed of three members, RUNX1/AML1, RUNX2 and RUNX3, and encodes the DNA-binding (α) subunits of the Runt domain transcription factor polyomavirus enhancer-binding protein 2 (PEBP2)/core-binding factor (CBF), which is a heterodimeric transcription factor. RUNX1 is most frequently involved in human acute leukemia. RUNX2 shows oncogenic potential in mouse experimental system. RUNX3 is a strong candidate as a gastric cancer tumor suppressor. The β subunit gene of PEBP2/CBF is also frequently involved in chromosome rearrangements associated with human leukemia. In this Overview, I will summarize how this growing field has been formed and what are the challenging new frontiers for better understanding of the oncogenic potential of this gene family.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 17, 2018
WEB OF SCIENCETM
checked on Nov 17, 2017
checked on Jan 21, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.