Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.molcel.2009.02.015
DC Field | Value | |
---|---|---|
dc.title | From Promiscuity to Precision: Protein Phosphatases Get a Makeover | |
dc.contributor.author | Virshup, D.M. | |
dc.contributor.author | Shenolikar, S. | |
dc.date.accessioned | 2016-12-13T05:39:15Z | |
dc.date.available | 2016-12-13T05:39:15Z | |
dc.date.issued | 2009-03-13 | |
dc.identifier.citation | Virshup, D.M., Shenolikar, S. (2009-03-13). From Promiscuity to Precision: Protein Phosphatases Get a Makeover. Molecular Cell 33 (5) : 537-545. ScholarBank@NUS Repository. https://doi.org/10.1016/j.molcel.2009.02.015 | |
dc.identifier.issn | 10972765 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/133023 | |
dc.description.abstract | The control of biological events requires strict regulation using complex protein phosphorylation and dephosphorylation strategies. The bulk of serine-threonine dephosphorylations are catalyzed by a handful of phosphatase catalytic subunits, giving rise to the misconception that these phosphatases are promiscuous and unregulated enzymes in vivo. The reality is much more nuanced: PP1 and PP2A, the most abundant serine-threonine phosphatases, are, in fact, families of hundreds of protein serine/threonine phosphatases, assembled from a few catalytic subunits in combination with a highly diverse array of regulators. As recent publications illustrate, these regulatory subunits confer specificity, selectivity, localization, and regulation on these important enzymes. © 2009 Elsevier Inc. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.molcel.2009.02.015 | |
dc.source | Scopus | |
dc.type | Review | |
dc.contributor.department | DUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE | |
dc.description.doi | 10.1016/j.molcel.2009.02.015 | |
dc.description.sourcetitle | Molecular Cell | |
dc.description.volume | 33 | |
dc.description.issue | 5 | |
dc.description.page | 537-545 | |
dc.description.coden | MOCEF | |
dc.identifier.isiut | 000264237800001 | |
Appears in Collections: | Staff Publications |
Show simple item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.