Please use this identifier to cite or link to this item:
|Title:||Neuroendocrine-immune interactions in fish: A role for interleukin-1|
Van Muiswinkel, W.B.
Verburg-Van Kemenade, B.M.L.
|Source:||Engelsma, M.Y., Huising, M.O., Van Muiswinkel, W.B., Flik, G., Kwang, J., Savelkoul, H.F.J., Verburg-Van Kemenade, B.M.L. (2002). Neuroendocrine-immune interactions in fish: A role for interleukin-1. Veterinary Immunology and Immunopathology 87 (3-4) : 467-479. ScholarBank@NUS Repository. https://doi.org/10.1016/S0165-2427(02)00077-6|
|Abstract:||Bi-directional communication between the hypothalamus-pituitary-adrenal (HPA)-axis and the sympathetic nervous system with the immune system is crucial to ensure homeostasis. Shared use of ligands and especially receptors forms a key component of this bi-directional interaction. Glucocorticoids (GC), the major end products of the HPA-axis differentially modulate immune function. Cytokines, especially interleukin-1 (IL-1), tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6), ensure immune signalling to the neuroendocrine system. In addition, hormones from leukocyte origin such as corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and β-endorphin, as well as centrally synthesised and secreted cytokines, contribute to the communication network. In teleost fish cortisol is the major product of the hypothalamus-pituitary-interrenal (HPI)-axis which is the teleost equivalent of the HPA-axis. Moderate and substantial increases in cortisol during stressful circumstances negatively affect B-lymphocytes, whereas rescue of neutrophilic granulocytes may support innate immunity. Recent elucidation of lower vertebrate cytokine sequences has facilitated research into neuroendocrine-immune interactions in teleosts and the first evidence for a significant function of interleukin-1 in the bi-directional communication is discussed. © 2002 Elsevier Science B.V. All rights reserved.|
|Source Title:||Veterinary Immunology and Immunopathology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 24, 2018
WEB OF SCIENCETM
checked on Nov 18, 2017
checked on Jan 21, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.