Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/132874
Title: Integrated immunogenomics in the chicken: Deciphering the immune response to identify disease resistance genes
Authors: Kaiser, P.
Howell, J.
Fife, M.
Sadeyen, J.-R.
Salmon, N.
Rothwell, L.
Young, J.
Van Diemen, P.
Stevens, M.
Poh, T.-Y. 
Jones, M.
Barrow, P.
Wigley, P.
He, H.
Swaggerty, C.
Kogut, M.
Smith, J.
Burt, D.
Keywords: Chemokine
Cytokine
eQTL
Innate immunity
SNP
TLR
Issue Date: 2008
Source: Kaiser, P., Howell, J., Fife, M., Sadeyen, J.-R., Salmon, N., Rothwell, L., Young, J., Van Diemen, P., Stevens, M., Poh, T.-Y., Jones, M., Barrow, P., Wigley, P., He, H., Swaggerty, C., Kogut, M., Smith, J., Burt, D. (2008). Integrated immunogenomics in the chicken: Deciphering the immune response to identify disease resistance genes. Developments in Biologicals 132 : 57-66. ScholarBank@NUS Repository.
Abstract: Resistance to infection takes place at many levels, and involves both non-specific and specific immune mechanisms. The chicken has a different repertoire of immune genes, molecules, cells and organs compared to mammals. To understand the role of any disease resistance gene(s), it is therefore important to understand these different repertoires, and the bird's response to a particularpathogen. Ourstudies focus on the innate immune response, as responses of macrophages from inbred lines of chickens, and heterophils from commercial birds, correlate with resistance or susceptibility to Salmonella infection with a variety of Salmonella serovars and infection models. To map disease resistance genes, we are using a combination of expression quantitative trait loci (eQTLs) from microarray studies, allied with whole genome SNP arrays (WGA) and a candidate gene approach. There are over 500 human genes with the Gene Ontology term "innate immunity." We have identified over 400 of these genes in the chicken genome, and are actively identifying informative SNPs in them. The segregation of 6,000 WGA SNPs across all of our inbred lines was also assessed, which should yield approximately 900 informative SNPs for a cross between any two lines. The initial focus of these studies is on mapping resistance genes in our inbred lines, but the studies will be extended to commercial flocks.
Source Title: Developments in Biologicals
URI: http://scholarbank.nus.edu.sg/handle/10635/132874
ISBN: 9783805586191
ISSN: 14246074
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

20
checked on Jan 21, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.