A study to assess the role of peroxisome proliferators- activated receptor-Gamma ligation on NA+/H+ Exchanger 1 Gene expression in breast Cancer cells : A potential new approach to Tumour cells' sensitization to cytotoxic drugs

Abstract

Ligand activation of peroxisome proliferator-activated receptor gamma (PPARN3) has been shown to inhibit proliferation and induce apoptosis in human tumor cell types; however the molecular mechanism underlying these effects has not been fully elucidated. Recently, we identified regulation of Na+/H+ exchanger 1 (NHE1) gene expression as a mechanism involved in reactive oxygen species (ROS) mediated regulation of tumor cellsb