Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/132741
Title: Picornavirus replication inhibitors HBB and guanidine in the echovirus-9 system: The significance of viral protein 2C
Authors: Klein, M.
Hadaschik, D.
Zimmermann, H. 
Eggers, H.J.
Nelsen-Salz, B.
Issue Date: 2000
Source: Klein, M., Hadaschik, D., Zimmermann, H., Eggers, H.J., Nelsen-Salz, B. (2000). Picornavirus replication inhibitors HBB and guanidine in the echovirus-9 system: The significance of viral protein 2C. Journal of General Virology 81 (4) : 895-901. ScholarBank@NUS Repository.
Abstract: HBB [2-(α-hydroxybenzyl)-benzimidazole] and guanidine are potent inhibitors of picornavirus replication. Among other evidence, limited cross-resistance and a synergistic effect of both inhibitors suggest similar but not identical mechanisms of antiviral action. Echovirus-9 variants resistant to each of these drugs were characterized and sequenced. Complete resistance to HBB or guanidine was shown to be due to single but different point mutations in the non-structural protein 2C. Protein 2C was expressed as GST fusion and His-tagged proteins for the wild-type and various mutants. Although three mutations were located in or near conserved NTP binding motifs, NTPase activity was not altered in the presence of HBB or guanidine.
Source Title: Journal of General Virology
URI: http://scholarbank.nus.edu.sg/handle/10635/132741
ISSN: 00221317
Appears in Collections:Staff Publications

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