Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.cellbi.2005.01.009
Title: In vitro developmental expression of dystroglycan and laminin-α2 in human skeletal muscle
Authors: Chen, L. 
Burgunder, J.-M.
Keywords: α- and β-dystroglycan
Development
Human skeletal muscle
Laminin-α2
Post-translational modification
Issue Date: Jul-2005
Source: Chen, L., Burgunder, J.-M. (2005-07). In vitro developmental expression of dystroglycan and laminin-α2 in human skeletal muscle. Cell Biology International 29 (7) : 506-513. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cellbi.2005.01.009
Abstract: The α-subunit of dystroglycan, a member of the dystrophin associated protein complex, binds to extracellular laminin-α2, while its β-subunit interacts with cytoskeletal dystrophin. The exact biological role of dystroglycan, especially during human skeletal muscle development, has not been fully explored. Here, we analysed the distribution and expression characteristics of both dystroglycan subunits and laminin-α2 in primary human skeletal muscle cells. During development, expression levels of all three proteins increased with differentiation. The proteins were relocated from the sarcoplasm to the sarcolemma. The size of α-dystroglycan decreased from 150-220 kDa at the proliferation stage to 100-120 kDa at the late developmental stage. Both α- and β-dystroglycan were involved in forming a complex with their respective partners laminin-α2 and dystrophin/utrophin. Our data show that, during development, cells may employ tightly regulated post-translational species-specific modification to produce different isoforms of α-dystroglycan to participate in appropriate functions. © 2005 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
Source Title: Cell Biology International
URI: http://scholarbank.nus.edu.sg/handle/10635/132715
ISSN: 10656995
DOI: 10.1016/j.cellbi.2005.01.009
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

1
checked on Jan 9, 2018

WEB OF SCIENCETM
Citations

1
checked on Nov 5, 2017

Page view(s)

9
checked on Jan 14, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.