Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/13271
Title: Design of macromolecular and supramolecular architecture as functional materials
Authors: LIU KERH LI
Keywords: Self-assemby, Block copolymer, Poly(3-hydroxybutyrate), Poly(ethylene glycol), Cyclodextrins, Host-guest chemistry
Issue Date: 21-May-2008
Source: LIU KERH LI (2008-05-21). Design of macromolecular and supramolecular architecture as functional materials. ScholarBank@NUS Repository.
Abstract: Amphiphilic block copolymers with poly(3-hydroxybutyrate) (PHB) and poly(ethylene glycol) (PEG) segments of different macromolecular architectures were synthesized and thoroughly characterized. With different macromolecular architectures, various self-assembly behaviors leading to supramolecular architectures such as thin films with lamellar morphology, spherical micelle of core-shell structure and physically cross-linked hydrogel were observed. Harnessing their amphiphilic nature, good biocompatibility and self-assembly property, the block copolymers were accessed for their potential biomedical applications. Multiblock PHB-alt-PEGs imparted tremendous multidimensional enhancements to PHBV through blending and hence render the blends good biomaterials candidate as tissue engineering scaffold. Micelles obtained from PHB-PEG-PHB triblock copolymers have good potential as nanocarrier in drug delivery systems for their stability towards dilution and temperature fluctuations. Hydrogels resulted from PHB-PEG-PHB/&#945-cyclodextrin polypseudorotaxanes demonstrated good strength and maybe used as depot in controlled drug release applications. This study also exemplifies the bottom-up approach towards biodegradable nanostructured materials with PHB-based materials.
URI: http://scholarbank.nus.edu.sg/handle/10635/13271
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