Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/132591
Title: Mutations in the promoter region of the androgen receptor gene are not common in males with idiopathic infertility
Authors: Ghadessy, F.J. 
Liow, S.L. 
Yong, E.L. 
Keywords: Androgen receptor
Gene
Infertility
Promoter
Issue Date: Mar-1999
Source: Ghadessy, F.J., Liow, S.L., Yong, E.L. (1999-03). Mutations in the promoter region of the androgen receptor gene are not common in males with idiopathic infertility. Molecular Human Reproduction 5 (3) : 287-290. ScholarBank@NUS Repository.
Abstract: Molecular studies on the role of the androgen receptor in male infertility have thus far concentrated solely on exonic regions of the androgen receptor gene. We have therefore screened for the first time the androgen receptor gene 5' untranslated region (nucleotides -153 to +237) in 240 males with idiopathic infertility for lesions which could potentially impair spermatogenesis. This region encompasses the androgen receptor gene promoter. DNA was extracted from blood leukocytes and the polymerase chain reaction was used to amplify the promoter region as two overlapping products. Single strand conformational polymorphism analysis was carried out on these products to screen for mutations. This analysis did not reveal the presence of any gross deletions or mutations. Our results thus preclude aberrations in the promoter region of the androgen receptor gene as a common factor in the aetiology of idiopathic male infertility.
Source Title: Molecular Human Reproduction
URI: http://scholarbank.nus.edu.sg/handle/10635/132591
ISSN: 13609947
Appears in Collections:Staff Publications

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