Please use this identifier to cite or link to this item:
|Title:||HLA-A2 allelic microvariants in nasopharyngeal carcinoma|
|Authors:||Ren, E.C. |
|Source:||Ren, E.C., Law, G.C.T., Chan, S.H. (1995). HLA-A2 allelic microvariants in nasopharyngeal carcinoma. International Journal of Cancer 63 (2) : 213-215. ScholarBank@NUS Repository. https://doi.org/10.1002/ijc.2910630211|
|Abstract:||HLA-A2 positive nasopharyngeal carcinoma (NPC; n = 38) and normal control (n = 51) populations were analysed by high-resolution oligotyping to identify A2 allelic microvariants. Within the control group, A*0207 was found to be the most common allele, accounting for 50% of the A2 frequency in normals. In contrast, this allele was found to be present in only 23% of NPC cases, suggesting a protective effect. Of these 9 NPC patients with A*0207, all were associated with B46, unlike in the control group, where it can be found associated with non-B46 antigens. Another allele, A*0201, which was thought to be protective against NPC was in fact present in 39.5% of NPC patients, more than twice the frequency in controls. These data confirm that A*0201 is not, a protective allele for NPC, and other factors such as the A*0207, non-B46 haplotype are of greater importance.|
|Source Title:||International Journal of Cancer|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 17, 2018
WEB OF SCIENCETM
checked on Nov 16, 2017
checked on Jan 14, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.