Please use this identifier to cite or link to this item: https://doi.org/10.1258/0956462961917267
Title: The potential role of azithromycin in the treatment or prophylaxis of toxoplasmosis
Authors: Chang, H.R. 
Keywords: Azalides
Azithromycin
Macrolides
Toxoplasma gondii
Toxoplasmosis
Issue Date: 1996
Citation: Chang, H.R. (1996). The potential role of azithromycin in the treatment or prophylaxis of toxoplasmosis. International Journal of STD and AIDS 7 (SUPPL. 1) : 18-22. ScholarBank@NUS Repository. https://doi.org/10.1258/0956462961917267
Abstract: Infection with Toxoplasma gondii is the most common parasitic infection worldwide with an estimated prevalence of 1-2 billion people. The risk of developing severe toxoplasmosis is higher for immunocompromised individuals and fetuses of mothers who have acquired a prime-infection. The current therapy of choice for toxoplasmosis is the synergistic combination of pyrimethamine, and sulphadiazine. This therapy is highly effective but its use is complicated in immunocompromised individuals due to adverse secondary effects. In addition, since pyrimethamine is potentially teratogenic, its use is not recommended during early pregnancy. Clindamycin, a Lincosaminide, in combination with pyrimethamine has been shown to be an acceptable therapeutic alternative in patients who are unable to tolerate pyrimethamine plus sulphadiazine. In the search for new, effective compounds with less adverse or toxic effects, recent efforts have focused on the new macrolides and the azalides. Here,. the results of the investigations and, in particular, the theoretical considerations for the potential use of azithromycin in the therapy of toxoplasmosis in immunocompromised individuals are reviewed.
Source Title: International Journal of STD and AIDS
URI: http://scholarbank.nus.edu.sg/handle/10635/132059
ISSN: 09564624
DOI: 10.1258/0956462961917267
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