Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/13195
Title: Fabrication, surface modification and growth factor encapsulation of polymeric microspheres as scaffold for liver tissue regeneration
Authors: ZHU XINHAO
Keywords: Tissue engineering, scaffold, polymeric microsphere, surface modification, growth factor, liver regeneration
Issue Date: 5-May-2008
Source: ZHU XINHAO (2008-05-05). Fabrication, surface modification and growth factor encapsulation of polymeric microspheres as scaffold for liver tissue regeneration. ScholarBank@NUS Repository.
Abstract: Tissue engineering has emerged as a promising alternative to traditional surgical procedures in regenerating or repairing damaged organs. One of the major strategies of tissue engineering is to culture isolated cells on a three-dimensional scaffold, which can be developed into a functional tissue with proper stimulation. In this study, the viability of using a novel microsphere scaffolding system to regenerate liver tissue was investigated. Liver cells grown on microsphere scaffold showed higher proliferation rate as well as improved hepatic functions compared to two-dimensional controls. The microsphere scaffold can be easily assembled into various shapes suitable for surgical implantation. It also offers controllable surface modification, growth factor encapsulation properties as well as in vitro vascularization, which show great promise for the production of a complete liver tissue engineering system to solve the shortage of liver donors.
URI: http://scholarbank.nus.edu.sg/handle/10635/13195
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
ZHUXINHAO(Ph.D Thesis).pdf5.8 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

299
checked on Dec 11, 2017

Download(s)

324
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.